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In the context of submitting a point-of-sale prescription claim, the lot number is not necessary. The lot number primarily pertains to the manufacturing batch of a medication, which relates to quality control and tracking of products rather than individual patient insurance verification.

On the other hand, the BIN (Bank Identification Number) is essential as it helps identify the processor of the claim. The cardholder ID number is crucial for identifying the specific individual who holds the insurance policy and is responsible for the claim. Patient gender may also be required to ensure that the medication is appropriate for the patient based on gender-specific considerations in prescriptions and treatments.